Solid lipid nanoparticles of clobetasol for psoriasis

SLN possess a solid matrix, which has the potential to modulate the drug release over a prolonged period of time13,14 with a reduced rate of systemic absorption. Optimized Cp-SLN was smooth and spherical under scanning electron microscopy; with average particle size of nm and per cent drug entrapment of Supernatant was separated and analyzed for drug content.

Topical drug delivery system, which provides higher skin retention of drug on target cells improves therapeutic response and reduces adverse effects of plain drug therapy Dual drug-loaded NLCs exhibited reduced skin permeation of calcipotriol but not methotrexate.

Clobetasol propionate, Solid lipid nanoparticles, High pressure homogenization technique, Mean flux, Chronic eczema. Int Cl7 A61 P Eczema is a reaction pattern in which primary lesions clinically manifest as pruritus, erythema, oedema, papules, vesicles, scaling, and lichenification1.

Calcipotriol-loaded NLC systems provided drug fluxes of 0. Aetiopathogenesis of eczema is not definite, but it may be the common final expression of allergic conditions such as atophic dermatitis, contact dermatitis or seborrhoeic dermatitis2.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. Cetyl alcohol, stearic acid and Tween 80 were purchased from S.

Indian Journal of Experimental Biology Vol. Cp is a potent topical glucocorticoid; found valuable in the treatment of various dermatological diseases and for controlling exacerbations of pruritic eczema and psoriasis2.

Results suggest that NLCs may have the potential to serve as delivery carriers for antipsoriatic drugs because of enhanced drug permeation and limited skin irritation.

It is characterized by excessive growth and aberrant differentiation of keratinocytes. Cp was dissolved in the lipid melt by sonication at W for 15 sec using probe sonicator V33 Vibronics Pvt.

Each experiment was repeated thrice and optimized batch was repeated 6 times on 6 different days to ascertain reproducibility as shown in Table 3. Topical Cp-SLN formulation17 has been diffusely reported in the literature and the clinical performance of the formulation has not been studied.

These two drugs with extremely different polarities can successfully be combined in NLCs. The particle size, surface charge, molecular environment, drug permeation, and skin irritation of the carriers were assessed.

This article has been cited by other articles in PMC. Hence, the aim of the present study was to develop Cp loaded SLN topical cream to increase skin uptake of the drug and provide prolonged effect to improve therapeutic index with reduced systemic absorption rate and toxicity.

Corticosteroids are thought to act by induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. Sixteen chronic eczema patients were enrolled in a controlled double blind clinical trial.

Preparation of Cp-SLN—Solid lipid nanoparticles loaded with Cp were prepared using high-pressure homogenization technique as described by Muller et al18, Drug permeation and skin uptake studies from Cp creams were carried out in a validated Franz static diffusion cell across human cadaver skin HCS.

It resulted into optimized combinations of independent variables only in nine experiments Table 2. The range of particle size of the NLC preparations was to nm, with vehicles containing a higher Precirol amount exhibiting a larger diameter.

Taguchi orthogonal experimental design20 was used to optimize the combination of four independent variables type of lipid, drug: The methotrexate amount permeating the skin was 2.

Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery

In recent years, solid lipid nanoparticles SLN have been used in topical drug formulations and are proven clinically as superior to plain drug topical therapyLipid nanoparticles for improved topical application of drugs for skin diseases To improve treatment of inflammatory skin diseases such as atopic eczema and psoriasis by glucocorticoids and T-cell inhibitors M.

FangPreparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system. On considering various lipid-based carrier systems, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are considered to be the most suitable ones [8 Souto E, Doktorovova S, Boonme P, et al.

Lipid-based colloidal systems (nanoparticles, microemulsions) for drug delivery to the skin: materials and end-product formulations. Jul 31,  · Solid lipid nanoparticles loaded topical gel containing combination drugs. 45 years of FC e &T of Cracow u niversity of Technology • nr 10/ • tom 65 Solid Lipid Nanoparticles – characteristics, application and obtaining Elwira LASoŃ, Jan oGonoWSKI – Institute of organic Chemistry and Technology, Cracow University.

The combination of calcipotriol with methotrexate can strengthen the topical therapy for psoriasis. The aim of the present study was to evaluate the potential of nanostructured lipid carriers (NLCs) loaded with lipophilic calcipotriol and hydrophilic methotrexate as topical therapy.

Clobetasol propionate followed by calcipotriol is superior to calcipotriol alone in topical treatment of psoriasis The superiority of the clobetasol propionate followed by calcipotriol treatment was maintained during a 4-week, treatment-free, observation period.

Sameer S. Katiyar, Varun Kushwah, Sanyog Jain, Solid lipid nanoparticles.

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Solid lipid nanoparticles of clobetasol for psoriasis
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